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Chronic myocardial ischemia

MedGen UID:
538766
•Concept ID:
C0264694
•
Disease or Syndrome
Synonym: Chronic ischemic heart disease
SNOMED CT: Chronic ischemic heart disease (413838009); Chronic myocardial ischemia (413844008)

Professional guidelines

PubMed

ACR Appropriateness Criteria® Chronic Chest Pain-High Probability of Coronary Artery Disease: 2021 Update.
Expert Panel on Cardiac Imaging, Litmanovich D, Hurwitz Koweek LM, Ghoshhajra BB, Agarwal PP, Bourque JM, Brown RKJ, Davis AM, Fuss C, Johri AM, Kligerman SJ, Malik SB, Maroules CD, Meyersohn NM, Vasu S, Villines TC, Abbara S
J Am Coll Radiol 2022 May;19(5S):S1-S18. doi: 10.1016/j.jacr.2022.02.021. PMID: 35550795
Personalized Management of Cardiovascular Disorders.
Jain KK
Med Princ Pract 2017;26(5):399-414. Epub 2017 Sep 11 doi: 10.1159/000481403. PMID: 28898880Free PMC Article
ACR Appropriateness Criteria(®) Chronic Chest Pain-High Probability of Coronary Artery Disease.
Expert Panel on Cardiac Imaging:, Akers SR, Panchal V, Ho VB, Beache GM, Brown RKJ, Ghoshhajra BB, Greenberg SB, Hsu JY, Kicska GA, Min JK, Stillman AE, Stojanovska J, Abbara S, Jacobs JE
J Am Coll Radiol 2017 May;14(5S):S71-S80. doi: 10.1016/j.jacr.2017.01.034. PMID: 28473096

Recent clinical studies

Etiology

Predicting Chronic Myocardial Ischemia Using CCTA-Based Radiomics Machine Learning Nomogram.
Shu ZY, Cui SJ, Zhang YQ, Xu YY, Hung SC, Fu LP, Pang PP, Gong XY, Jin QY
J Nucl Cardiol 2022 Feb;29(1):262-274. Epub 2020 Jun 18 doi: 10.1007/s12350-020-02204-2. PMID: 32557238
Thymosin β4-mediated protective effects in the heart.
Hinkel R, Klett K, Bähr A, Kupatt C
Expert Opin Biol Ther 2018 Jul;18(sup1):121-129. doi: 10.1080/14712598.2018.1490409. PMID: 30063857
Personalized Management of Cardiovascular Disorders.
Jain KK
Med Princ Pract 2017;26(5):399-414. Epub 2017 Sep 11 doi: 10.1159/000481403. PMID: 28898880Free PMC Article
Adipose-derived stem cell sheet transplantation therapy in a porcine model of chronic heart failure.
Ishida O, Hagino I, Nagaya N, Shimizu T, Okano T, Sawa Y, Mori H, Yagihara T
Transl Res 2015 May;165(5):631-9. Epub 2014 Dec 31 doi: 10.1016/j.trsl.2014.12.005. PMID: 25613060
Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications.
Waltenberger J
Cardiovasc Res 2001 Feb 16;49(3):554-60. doi: 10.1016/s0008-6363(00)00228-5. PMID: 11166268

Diagnosis

Differentiating Macrovascular and Microvascular Ischemia Using Fractal Analysis of Dynamic Myocardial Perfusion Stress-CT.
Michallek F, Nakamura S, Kurita T, Ota H, Nishimiya K, Ogawa R, Shizuka T, Nakashima H, Wang YN, Ito T, Sakuma H, Dewey M, Kitagawa K
Invest Radiol 2024 May 1;59(5):413-423. Epub 2023 Oct 9 doi: 10.1097/RLI.0000000000001027. PMID: 37812495
Air Pollution and Coronary Vasomotor Disorders in Patients With Myocardial Ischemia and Unobstructed Coronary Arteries.
Camilli M, Russo M, Rinaldi R, Caffè A, La Vecchia G, Bonanni A, Iannaccone G, Basile M, Vergallo R, Aurigemma C, Trani C, Niccoli G, Crea F, Montone RA
J Am Coll Cardiol 2022 Nov 8;80(19):1818-1828. Epub 2022 Aug 29 doi: 10.1016/j.jacc.2022.08.744. PMID: 36049556
Predicting Chronic Myocardial Ischemia Using CCTA-Based Radiomics Machine Learning Nomogram.
Shu ZY, Cui SJ, Zhang YQ, Xu YY, Hung SC, Fu LP, Pang PP, Gong XY, Jin QY
J Nucl Cardiol 2022 Feb;29(1):262-274. Epub 2020 Jun 18 doi: 10.1007/s12350-020-02204-2. PMID: 32557238
Personalized Management of Cardiovascular Disorders.
Jain KK
Med Princ Pract 2017;26(5):399-414. Epub 2017 Sep 11 doi: 10.1159/000481403. PMID: 28898880Free PMC Article
Clinical effects of ischemic preconditioning.
Schwarz ER, Reffelmann T, Kloner RA
Curr Opin Cardiol 1999 Jul;14(4):340-8. doi: 10.1097/00001573-199907000-00010. PMID: 10448615

Therapy

Mesenchymal stem cells and inflammatory lung diseases.
Iyer SS, Co C, Rojas M
Panminerva Med 2009 Mar;51(1):5-16. PMID: 19352305
Therapeutic myocardial angiogenesis.
Renault MA, Losordo DW
Microvasc Res 2007 Sep-Nov;74(2-3):159-71. Epub 2007 Sep 7 doi: 10.1016/j.mvr.2007.08.005. PMID: 17950369Free PMC Article
Angiogenic protein therapy.
Ruel M, Sellke FW
Semin Thorac Cardiovasc Surg 2003 Jul;15(3):222-35. doi: 10.1016/s1043-0679(03)70002-1. PMID: 12973700
VEGF-2 (St Elizabeth's Medical Center).
Yeung PK
Curr Opin Investig Drugs 2001 Jun;2(6):796-800. PMID: 11572659
Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications.
Waltenberger J
Cardiovasc Res 2001 Feb 16;49(3):554-60. doi: 10.1016/s0008-6363(00)00228-5. PMID: 11166268

Prognosis

Differentiating Macrovascular and Microvascular Ischemia Using Fractal Analysis of Dynamic Myocardial Perfusion Stress-CT.
Michallek F, Nakamura S, Kurita T, Ota H, Nishimiya K, Ogawa R, Shizuka T, Nakashima H, Wang YN, Ito T, Sakuma H, Dewey M, Kitagawa K
Invest Radiol 2024 May 1;59(5):413-423. Epub 2023 Oct 9 doi: 10.1097/RLI.0000000000001027. PMID: 37812495
Air Pollution and Coronary Vasomotor Disorders in Patients With Myocardial Ischemia and Unobstructed Coronary Arteries.
Camilli M, Russo M, Rinaldi R, Caffè A, La Vecchia G, Bonanni A, Iannaccone G, Basile M, Vergallo R, Aurigemma C, Trani C, Niccoli G, Crea F, Montone RA
J Am Coll Cardiol 2022 Nov 8;80(19):1818-1828. Epub 2022 Aug 29 doi: 10.1016/j.jacc.2022.08.744. PMID: 36049556
Predicting Chronic Myocardial Ischemia Using CCTA-Based Radiomics Machine Learning Nomogram.
Shu ZY, Cui SJ, Zhang YQ, Xu YY, Hung SC, Fu LP, Pang PP, Gong XY, Jin QY
J Nucl Cardiol 2022 Feb;29(1):262-274. Epub 2020 Jun 18 doi: 10.1007/s12350-020-02204-2. PMID: 32557238
ACR Appropriateness Criteria(®) Chronic Chest Pain-High Probability of Coronary Artery Disease.
Expert Panel on Cardiac Imaging:, Akers SR, Panchal V, Ho VB, Beache GM, Brown RKJ, Ghoshhajra BB, Greenberg SB, Hsu JY, Kicska GA, Min JK, Stillman AE, Stojanovska J, Abbara S, Jacobs JE
J Am Coll Radiol 2017 May;14(5S):S71-S80. doi: 10.1016/j.jacr.2017.01.034. PMID: 28473096
Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications.
Waltenberger J
Cardiovasc Res 2001 Feb 16;49(3):554-60. doi: 10.1016/s0008-6363(00)00228-5. PMID: 11166268

Clinical prediction guides

Differentiating Macrovascular and Microvascular Ischemia Using Fractal Analysis of Dynamic Myocardial Perfusion Stress-CT.
Michallek F, Nakamura S, Kurita T, Ota H, Nishimiya K, Ogawa R, Shizuka T, Nakashima H, Wang YN, Ito T, Sakuma H, Dewey M, Kitagawa K
Invest Radiol 2024 May 1;59(5):413-423. Epub 2023 Oct 9 doi: 10.1097/RLI.0000000000001027. PMID: 37812495
Air Pollution and Coronary Vasomotor Disorders in Patients With Myocardial Ischemia and Unobstructed Coronary Arteries.
Camilli M, Russo M, Rinaldi R, Caffè A, La Vecchia G, Bonanni A, Iannaccone G, Basile M, Vergallo R, Aurigemma C, Trani C, Niccoli G, Crea F, Montone RA
J Am Coll Cardiol 2022 Nov 8;80(19):1818-1828. Epub 2022 Aug 29 doi: 10.1016/j.jacc.2022.08.744. PMID: 36049556
Predicting Chronic Myocardial Ischemia Using CCTA-Based Radiomics Machine Learning Nomogram.
Shu ZY, Cui SJ, Zhang YQ, Xu YY, Hung SC, Fu LP, Pang PP, Gong XY, Jin QY
J Nucl Cardiol 2022 Feb;29(1):262-274. Epub 2020 Jun 18 doi: 10.1007/s12350-020-02204-2. PMID: 32557238
PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia.
Wang X, Li X, Liu S, Brickell AN, Zhang J, Wu Z, Zhou S, Ding Z
Basic Res Cardiol 2020 Nov 12;115(6):66. doi: 10.1007/s00395-020-00832-w. PMID: 33180196
Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications.
Waltenberger J
Cardiovasc Res 2001 Feb 16;49(3):554-60. doi: 10.1016/s0008-6363(00)00228-5. PMID: 11166268

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